A TEAM of Chinese scientists has identified a longevity gene that may potentially enhance human resistance to aging and become a new target for managing pests. Mitochondria, as the powerhouses of the cell, play a pivotal role in cellular energy production and are closely linked to the aging process. Research on extending lifespan through optimizing mitochondrial function has garnered considerable interest across the scientific community. Previous research has predominantly concentrated on mitochondria, while comparatively less emphasis has been placed on the influence of cell nuclei, which have undergone a long-term co-evolutionary process alongside mitochondria. The researchers from Zhejiang University and the Center for Excellence in Molecular Plant Sciences under the Chinese Academy of Sciences analyzed evolutionary changes of mitochondrial and nuclear genomes from 472 insects and identified 75 nuclear genes that co-evolve with mitochondrial genes. They pinpointed four genes, including one called CG11837, and undertook experiments to diminish their activities in fruit flies. The findings revealed that, in contrast to the control group, the diminished activity of these specific genes resulted in conspicuous alterations to the mitochondrial structure, according to the study published this week in the journal Nature Aging. Furthermore, the team discovered a significant positive correlation between the activity of CG11837 and the lifespan of the organism. They knocked down the gene across a spectrum of six distinct species, including brown plant hoppers, fruit flies, and mosquitoes, and the gene suppression led to a pronounced shortening of their lifespans, with the diminution ranging from 25% to 59%. In contrast, the overexpression of the gene is shown to extend median lifespans in fruit flies, according to the study. Also, in vitro studies using human cells have shown that the activation of the CG11837 gene boosts their capacity to combat aging, achieving a 30% enhancement. The activation of CG11837 may emerge as a novel strategy for extending human lifespan, and in the agricultural sector, this gene knockdown could potentially serve as a new way for pest control, said the researchers. (Xinhua) | 